Matracell

 



 

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Safely removes donor cells and DNA without sacrificing the biomechanical strength of the allograft bio-implant. Download the Matracell Brochure

What is it?

Matracell is a patented and validated process that renders allograft tissue acellular, without compromising the biomechanical or desired biochemical properties of an allograft bio-implant for its intended surgical application.

How does it work?

The Matracell process requires three steps:

Step One - Decellularization. Matracell utilizes an anionic, non-denaturing detergent, N-Lauroyl sarconsinate, to remove donor cells from the allograft bio-implant. N-Lauroyl sarcosinate is a common detergent used widely in cosmetic industry due to its bacteriodical properties and safety profile. To remove the donor DNA, a recombinant endonuclease, Benzonase® is applied to efficiently degrade the DNA without introducing the risk of prion disease transmission.

Step Two - Rinsing. Decellularization reagent residuals and donor cell remnants are removed from the allograft bio-implant. The process utilizes water that circulates through the allograft bio-implant and then a resin bed to remove the decellularization reagents and cell remnants from the water.

Step Three - Preservation. The allograft bio-implant is preserved with LifeNet Health’s proprietary technology that is comprised of USP glycerol and USP grade water. The allograft bio-implant is then cryopreserved or frozen and stored at -80ºC.

What does the data say?

Allograft bio-implants decellularized with Matracell technology have been successfully assessed in a large animal model for biocompatibility and durability. The processing reagents and biomechanical strength are thoroughly evaluated and the Matracell process is validated to remove >99% of the donor DNA. The end-point microbiological testing is validated in accordance with USP <71> and the end-point DNA testing is validated in accordance with ICH Harmonized Tripartite Guidelines Q2 (R1) “Validation of Analytical Procedures: Text and Methodology.”

Why choose MATRACELL™ Decellularized Allograft Bio-Implants?

Matracell renders allograft bio-implants acellular without compromising the biomechanical properties for their intended surgical applications, and is designed to reduce immunogenic components. Matracell is just another way LifeNet Health strives to provide allograft bio-implants to save lives, and restore health to thousands of patients annually.  

 





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